{"id":20688,"date":"2024-06-10T16:26:45","date_gmt":"2024-06-10T07:26:45","guid":{"rendered":"https:\/\/nofia.net\/?p=20688"},"modified":"2024-06-10T16:26:45","modified_gmt":"2024-06-10T07:26:45","slug":"%ef%bc%88%e3%83%a1%e3%83%a2%ef%bc%89%e3%80%8c%e8%a4%87%e6%96%b9%e4%b8%b9%e5%8f%82%e6%bb%b4%e4%b8%b8%e3%80%8d%e3%81%a8%e3%81%84%e3%81%86%e6%bc%a2%e6%96%b9%e3%81%8c%e3%80%81cgas-sting%e8%aa%98%e7%99%ba","status":"publish","type":"post","link":"https:\/\/nofia.net\/?p=20688","title":{"rendered":"\uff08\u30e1\u30e2\uff09\u300c\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u300d\u3068\u3044\u3046\u6f22\u65b9\u304c\u3001cGAS-STING\u8a98\u767a\u6027\u75be\u60a3\u3092\u52b9\u679c\u7684\u306b\u7de9\u548c\u3059\u308b\u3068\u3044\u3046\u8ad6\u6587"},"content":{"rendered":"<p style=\"padding-left: 40px;\">\n<span style=\"color: #808080;\">\u79c1\u306f\u3053\u306e\u300c cGAS-STING \u7d4c\u8def\u300d\u3068\u3044\u3046\u306e\u3092\u7406\u89e3\u3057\u3066\u3044\u306a\u3044\u306e\u3067\uff08\u7d30\u80de\u8cea\u5185\u306b\u304a\u3044\u3066\u4e8c\u672c\u9396DNA\u3092\u8a8d\u8b58\u3057\u3066\u3001I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3092\u4ecb\u3057\u305f\u9632\u5fa1\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u3089\u3057\u3044\uff09\u3001\u30e1\u30e2\u3068\u3057\u305f\u306e\u3067\u3059\u3051\u308c\u3069\u3001\u3082\u3057\u304b\u3059\u308b\u3068\u3001\u3053\u306e\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u3068\u3044\u3046\u3082\u306e\u304c\u3001\u30ef\u30af\u30c1\u30f3\u306e\u5f71\u97ff\u306a\u3069\u306b\u3088\u308b\u554f\u984c\u306b\u5bfe\u51e6\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u4f55\u3068\u3082\u3044\u3048\u306a\u3044\u3067\u3059\u304c\u3002<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">\u4e00\u822c\u7684\u306a\u8aac\u660e\u3067\u306f\u3001 cGAS-STING \u7d4c\u8def\u3068\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\"><span style=\"color: #000080;\">\uff1e cGAS-STING\u7d4c\u8def\u306f\u3001\u3082\u3068\u3082\u3068\uff0c\u30a6\u30a4\u30eb\u30b9\u304c\u5bbf\u4e3b\u306e\u7d30\u80de\u8cea\u306b\u3082\u3061\u8fbc\u3080\u201c\u975e\u81ea\u5df1DNA\u201d\u306b\u5fdc\u7b54\u3057\u3066\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3092\u6d3b\u6027\u5316\u3059\u308b\u7d4c\u8def\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u7d30\u80de\u8cea\u306b\u6f0f\u51fa\u3057\u305f\u201c\u81ea\u5df1DNA\u201d\u3067\u3042\u3063\u3066\u3082\u7d30\u80de\u8cea\u306b\u6f0f\u51fa\u3057\u3066\u672c\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u708e\u75c7\u75c5\u614b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u2026<\/span> \uff08<a href=\"https:\/\/www.yodosha.co.jp\/jikkenigaku\/articles\/index.html?ci=74900\" target=\"_blank\" rel=\"noopener\">yodosha.co.jp<\/a>\uff09<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u3068\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\"><span style=\"color: #000080;\">\uff1e \u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306f\u4e39\u53c2\u3001\u7530\u4e03\u3001\u6c37\u7247\u3092\u542b\u3080\u8907\u65b9\u88fd\u5264\u3067\u3001\u4e2d\u56fd\u306b\u304a\u3044\u3066\u306f\u3001\u72ed\u5fc3\u75c7\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u3066\u3044\u308b\u3002<\/span> \uff08<a href=\"http:\/\/www.chuigaku.co.jp\/media\/pdf\/prgrm.pdf\" target=\"_blank\" rel=\"noopener\">chuigaku.co.jp<\/a>\uff09<\/span><\/p>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6677469365582533\" crossorigin=\"anonymous\"><\/script><br \/>\n<!-- 0723b --><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block;\" data-ad-client=\"ca-pub-6677469365582533\" data-ad-slot=\"4320035992\" data-ad-format=\"auto\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/p>\n<hr \/>\n<h3><span style=\"color: #cb0000; font-size: 14pt;\">\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306fSTING-TBK1\u76f8\u4e92\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067cGAS-STING\u8a98\u767a\u6027\u75be\u60a3\u3092\u52b9\u679c\u7684\u306b\u7de9\u548c\u3059\u308b<\/span><\/h3>\n<p><span style=\"color: #808080; font-size: 10pt;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0944711324000692 \" target=\"_blank\" rel=\"noopener\">sciencedirect.com<\/a> 2024\/06<\/span><\/p>\n<p><strong><span style=\"font-size: 10pt; color: #999999;\">Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction<\/span><\/strong><\/p>\n<p><span style=\"font-size: 14pt; color: #800000;\"><strong>\u6982\u8981<\/strong><\/span><\/p>\n<p><span style=\"color: #800000;\"><strong>\u80cc\u666f<\/strong><\/span><\/p>\n<p><span style=\"color: #000080;\">\u74b0\u72b6\u30b0\u30a2\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\uff08cGAS\uff09-\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09\u907a\u4f1d\u5b50\u523a\u6fc0\u56e0\u5b50\uff08STING\uff09\u7d4c\u8def\u306f\u3001\u81ea\u7136\u514d\u75ab\u7cfb\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308a\u3001\u7d30\u80de\u8cea DNA \u306b\u3088\u3063\u3066\u52d5\u54e1\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3055\u307e\u3056\u307e\u306a<strong>\u708e\u75c7\u6027\u75be\u60a3\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u9032\u884c\u306f\u3001\u7570\u5e38\u306a cGAS-STING \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3068\u9ad8\u3044\u76f8\u95a2\u95a2\u4fc2\u306b\u3042\u308b<\/strong>\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3044\u304f\u3064\u304b\u306e cGAS-STING \u7d4c\u8def\u963b\u5bb3\u5264\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u81e8\u5e8a\u306b\u9069\u7528\u3067\u304d\u308b\u85ac\u5264\u306f\u306a\u3044\u3002\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\uff08CDDP\uff09\u306f\u3001\u4e16\u754c\u4e2d\u306e\u81e8\u5e8a\u3067\u52b9\u679c\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u6700\u3082\u4e00\u822c\u7684\u306a\u7528\u9014\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u9650\u3089\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3057\u305f\u304c\u3063\u3066\u3001\u672c\u8abf\u67fb\u306e\u76ee\u7684\u306f\u3001\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u304c cGAS-STING \u7d4c\u8def\u3092\u963b\u5bb3\u3057\u3001 cGAS-STING \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u8907\u6570\u306e\u75be\u60a3\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u3060\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #808080;\">\uff08\u7565\uff09<\/span><\/p>\n<p><span style=\"color: #800000;\"><strong>\u7d50\u679c<\/strong><\/span><\/p>\n<p><span style=\"color: #000080;\">\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306e\u52b9\u679c\u306f\u3001IRF3 <span style=\"color: #808080;\">\uff08\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u8abf\u7bc0\u56e0\u5b503\uff09<\/span>\u306e\u30ea\u30f3\u9178\u5316\u3084 IFN-\u03b2\u3001ISG\u3001IL-6\u3001TNF-\u03b1 \u306e\u751f\u6210\u3092\u6291\u5236\u3057\u305f\u3002\u6a5f\u69cb\u7684\u306b\u306f\u3001\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306f STING \u30aa\u30ea\u30b4\u30de\u30fc\u5316\u3084 IRF3-TBK1\u3001STING-IRF3 \u76f8\u4e92\u4f5c\u7528\u306b\u306f\u5f71\u97ff\u3057\u306a\u304b\u3063\u305f\u304c\u3001STING-TBK1 \u76f8\u4e92\u4f5c\u7528\u3092\u8457\u3057\u304f\u6392\u9664\u3057\u3001\u6700\u7d42\u7684\u306b\u4e0b\u6d41\u306e\u53cd\u5fdc\u3092\u963b\u5bb3\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3055\u3089\u306b\u3001\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306f\u3001\u751f\u4f53\u5185\u3067 DMXAA <span style=\"color: #808080;\">\uff08\u8840\u7ba1\u7834\u58ca\u5264\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\uff09<\/span>\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b cGAS-STING \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u4e00\u8cab\u3057\u3066\u3001\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306f Trex1 \u2212\/\u2212\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b<strong>\u591a\u81d3\u5668\u708e\u75c7\u53cd\u5fdc\u3092\u8efd\u6e1b\u3057<\/strong>\u3001\u80a5\u6e80\u8a98\u767a\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306a\u3069\u306e\u708e\u75c7\u6027\u75be\u60a3\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #800000;\"><strong>\u7d50\u8ad6<\/strong><\/span><\/p>\n<p><span style=\"color: #000080;\">\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306f cGAS-STING \u7d4c\u8def\u3092\u7279\u7570\u7684\u306b\u963b\u5bb3\u3059\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3055\u3089\u306b\u3001\u79c1\u305f\u3061\u306f\u3001\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u306e\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63d0\u4f9b\u3057\u3001<strong>cGAS-STING \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u708e\u75c7\u6027\u75be\u60a3\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u6cbb\u7642\u306e\u305f\u3081\u306e\u81e8\u5e8a\u85ac\u3092\u767a\u898b\u3057\u305f<\/strong>\u3002<\/span><\/p>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6677469365582533\" crossorigin=\"anonymous\"><\/script><br \/>\n<!-- 0723b --><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block;\" data-ad-client=\"ca-pub-6677469365582533\" data-ad-slot=\"4320035992\" data-ad-format=\"auto\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u79c1\u306f\u3053\u306e\u300c cGAS-STING \u7d4c\u8def\u300d\u3068\u3044\u3046\u306e\u3092\u7406\u89e3\u3057\u3066\u3044\u306a\u3044\u306e\u3067\uff08\u7d30\u80de\u8cea\u5185\u306b\u304a\u3044\u3066\u4e8c\u672c\u9396DNA\u3092\u8a8d\u8b58\u3057\u3066\u3001I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3092\u4ecb\u3057\u305f\u9632\u5fa1\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u3089\u3057\u3044\uff09\u3001\u30e1\u30e2\u3068\u3057\u305f\u306e\u3067\u3059\u3051\u308c\u3069\u3001\u3082\u3057\u304b\u3059\u308b\u3068\u3001\u3053\u306e\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38 &hellip; <a href=\"https:\/\/nofia.net\/?p=20688\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\uff08\u30e1\u30e2\uff09\u300c\u8907\u65b9\u4e39\u53c2\u6ef4\u4e38\u300d\u3068\u3044\u3046\u6f22\u65b9\u304c\u3001cGAS-STING\u8a98\u767a\u6027\u75be\u60a3\u3092\u52b9\u679c\u7684\u306b\u7de9\u548c\u3059\u308b\u3068\u3044\u3046\u8ad6\u6587<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":20359,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57],"tags":[],"class_list":["post-20688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/20688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20688"}],"version-history":[{"count":1,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/20688\/revisions"}],"predecessor-version":[{"id":20689,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/20688\/revisions\/20689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/media\/20359"}],"wp:attachment":[{"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}