{"id":19298,"date":"2024-04-09T17:16:37","date_gmt":"2024-04-09T08:16:37","guid":{"rendered":"https:\/\/nofia.net\/?p=19298"},"modified":"2024-04-27T11:09:36","modified_gmt":"2024-04-27T02:09:36","slug":"%e9%80%86%e6%b5%81%e6%80%a7%e9%a3%9f%e9%81%93%e7%82%8e%e3%82%84%e8%83%83%e6%bd%b0%e7%98%8d%e3%81%ab%e5%ba%83%e3%81%8f%e5%87%a6%e6%96%b9%e3%81%95%e3%82%8c%e3%82%8b%e3%83%97%e3%83%ad%e3%83%88%e3%83%b3","status":"publish","type":"post","link":"https:\/\/nofia.net\/?p=19298","title":{"rendered":"\u9006\u6d41\u6027\u98df\u9053\u708e\u3084\u80c3\u6f70\u760d\u306b\u5e83\u304f\u51e6\u65b9\u3055\u308c\u308b\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u306f\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u308b\u3068\u3044\u3046\u8ad6\u6587"},"content":{"rendered":"<p><span style=\"color: #808080;\">\uff08\u53c2\u8003\u8a18\u4e8b\uff09<a href=\"https:\/\/indeep.jp\/medication-ppi-has-linked-double-risk-of-stomach-cancer\/\" target=\"_blank\" rel=\"noopener\">\u80c3\u6f70\u760d\u3084\u9006\u6d41\u6027\u98df\u9053\u708e\u306b\u5e45\u5e83\u304f\u51e6\u65b9\u3055\u308c\u308b\u80c3\u85ac\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u300d\u306f\u80c3\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u3092\u6700\u5927\u30678\u500d\u306b\u307e\u3067\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u3002\u305d\u3057\u3066\u8178\u5185\u7d30\u83cc\u74b0\u5883\u3092\u7834\u58ca\u3059\u308b\u793a\u5506\u3082<\/a><\/span><br \/>\n<span style=\"color: #808080;\">In Deep 2019\u5e749\u670830\u65e5<\/span><\/p>\n<hr \/>\n<h3><span style=\"color: #cb0000;\">\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u3068\u30ac\u30f3\u306e\u30ea\u30b9\u30af<\/span><\/h3>\n<p><span style=\"color: #808080; font-size: 10pt;\"><a href=\"https:\/\/www.mdpi.com\/2077-0383\/13\/7\/1970# \" target=\"_blank\" rel=\"noopener\">mdpi.com<\/a> 2024\/03\/28<\/span><\/p>\n<p><strong><span style=\"font-size: 10pt; color: #999999;\">Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence<\/span><\/strong><\/p>\n<p><span style=\"font-size: 14pt; color: #800000;\"><strong>\u6982\u8981<\/strong><\/span><\/p>\n<p><span style=\"color: #000080;\">\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264 (PPI) \u306f\u3001\u4e00\u822c\u7684\u306b\u80c3\u9178\u9006\u6d41\u3001\u80c3\u98df\u9053\u9006\u6d41\u75c7 (GERD)\u3001\u304a\u3088\u3073\u6d88\u5316\u6027\u6f70\u760d\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u9577\u6642\u9593\u4f5c\u7528\u578b\u306e\u85ac\u3068\u3057\u3066\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u6700\u8fd1\u3001\u7279\u306b PPI \u306e\u9577\u671f\u4f7f\u7528\u3068\u30ac\u30f3\u306e\u767a\u751f\u3068\u306e\u95a2\u9023\u306b\u3088\u308a\u3001\u305d\u306e\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u61f8\u5ff5\u304c\u751f\u3058\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\"><strong>\u80cc\u666f\uff1a<\/strong>\u8907\u6570\u306e\u5305\u62ec\u7684\u306a\u7814\u7a76\u306f\u3001\u9577\u671f\u9593\u306e PPI \u4f7f\u7528\u3068\u3001\u80c3\u30ac\u30f3\u3001\u98df\u9053\u30ac\u30f3\u3001\u7d50\u8178\u76f4\u8178\u30ac\u30f3\u3001\u3059\u3044\u81d3\u30ac\u30f3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u5897\u52a0\u3068\u306e\u9593\u306e\u6ce8\u76ee\u3059\u3079\u304d\u95a2\u9023\u6027\u3092\u4e00\u8cab\u3057\u3066\u793a\u5506\u3057\u3066\u3044\u308b\u304c\u3001\u6b63\u78ba\u306a\u6839\u5e95\u306b\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4f9d\u7136\u3068\u3057\u3066\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\"><strong>\u65b9\u6cd5\uff1a<\/strong>\u307e\u305a\u3001\u30ac\u30f3\u3068 PPI \u306e\u8907\u96d1\u306a\u95a2\u4fc2\u3092\u8abf\u67fb\u3059\u308b\u5e83\u7bc4\u306a\u7814\u7a76\u3092\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u3002\u6b21\u306b\u3001ProTox-II \u30a6\u30a7\u30d6\u30b5\u30fc\u30d0\u30fc\u3067\u30d7\u30ed\u30c9\u30e9\u30c3\u30b0\u69cb\u9020\u3092\u4f7f\u7528\u3057\u3066 PPI \u6bd2\u6027\u3092\u4e88\u6e2c\u3059\u308b\u3002\u6700\u5f8c\u306b\u3001\u5404\u85ac\u5264\u306e PubMed \u5f15\u7528\u6570\u3068\u30ac\u30f3\u306b\u95a2\u9023\u3059\u308b\u30ad\u30fc\u30ef\u30fc\u30c9\u3092\u4f7f\u7528\u3057\u3066\u3001\u5404 PPI \u306e\u30ac\u30f3\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\"><strong>\u7d50\u679c\uff1a<\/strong>\u79c1\u305f\u3061\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001PPI \u306e\u9577\u671f\u4f7f\u7528\uff083\u304b\u6708\u4ee5\u4e0a\uff09\u306f\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u77ed\u671f\u9593\u306e\u4f7f\u7528\uff083\u304b\u6708\u672a\u6e80\uff09\u3067\u306f\u30ea\u30b9\u30af\u304c\u6bd4\u8f03\u7684\u4f4e\u3044\u3088\u3046\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u79c1\u305f\u3061\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u3001pH \u3068\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u306e\u5909\u5316\u3001\u30d3\u30bf\u30df\u30f3\u3068\u30df\u30cd\u30e9\u30eb\u306e\u5438\u53ce\u4e0d\u826f\u3001\u9ad8\u30ac\u30b9\u30c8\u30ea\u30f3\u8840\u75c7\u3001\u30a8\u30f3\u30c6\u30ed\u30af\u30ed\u30e0\u89aa\u548c\u6027\u7d30\u80de\u5897\u6b96\u306a\u3069\u3001\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\u3055\u307e\u3056\u307e\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7db2\u7f85\u3057\u3066\u304a\u308a\u3001ProTox-II \u306f\u30a2\u30ea\u30fc\u30eb\u70ad\u5316\u6c34\u7d20\u53d7\u5bb9\u4f53\u306e\u7d50\u5408\u3082\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">PubMed \u306e\u5f15\u7528\u6570\u306f\u3001PPI \u306e\u30aa\u30e1\u30d7\u30e9\u30be\u30fc\u30eb\u3068\u30e9\u30f3\u30bd\u30d7\u30e9\u30be\u30fc\u30eb<span style=\"color: #808080;\">\uff08\u3069\u3061\u3089\u3082PPI\uff09<\/span>\u304c\u3001\u30d1\u30f3\u30c8\u30d7\u30e9\u30be\u30fc\u30eb<span style=\"color: #808080;\">\uff08PPI \u3068\u540c\u7b49\u306e\u50cd\u304d\uff09<\/span>\u3084\u30a8\u30bd\u30e1\u30d7\u30e9\u30be\u30fc\u30eb<span style=\"color: #808080;\">\uff08PPI \uff09<span style=\"color: #000080;\">\u3088<\/span><\/span>\u308a\u3082\u30ac\u30f3\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u6bd4\u8f03\u3059\u308b\u3068\u3001H2R \u30d6\u30ed\u30c3\u30ab\u30fc\u3067\u3042\u308b\u30d5\u30a1\u30e2\u30c1\u30b8\u30f3\uff08\u30ac\u30b9\u30bf\u30fc\u306e\u3053\u3068\uff09\u306f PPI \u3088\u308a\u3082\u30ac\u30f3\u3068\u306e\u95a2\u9023\u6027\u304c\u4f4e\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u30013 \u304b\u6708\u3092\u8d85\u3048\u308b\u671f\u9593\u306e\u3088\u308a\u5b89\u5168\u306a\u4ee3\u66ff\u6cbb\u7642\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\"><strong>\u7d50\u8ad6\uff1a<\/strong>PPI \u306b\u95a2\u9023\u3059\u308b\u767a\u304c\u3093\u30ea\u30b9\u30af\u306f\u5341\u5206\u306b\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c 3\u304b\u6708\u3092\u8d85\u3048\u308b\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u5e83\u304f\u51e6\u65b9\u3055\u308c\u7d9a\u3051\u3066\u3044\u308b\u3053\u3068\u306f\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3057\u305f\u304c\u3063\u3066\u3001\u81e8\u5e8a\u533b\u3068\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u533b\u7642\u7ba1\u7406\u306b\u95a2\u3057\u3066\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u6c7a\u5b9a\u3092\u4e0b\u3059\u524d\u306b\u3001PPI \u306e\u9577\u671f\u4f7f\u7528\u306e\u6f5c\u5728\u7684\u306a\u30ea\u30b9\u30af\u3068\u5229\u70b9\u3092\u614e\u91cd\u306b\u8a55\u4fa1\u3057\u3001\u4ee3\u66ff\u6cbb\u7642\u6cd5\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u6700\u3082\u91cd\u8981\u3060\u3002<\/span><br \/>\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6677469365582533\" crossorigin=\"anonymous\"><\/script><br \/>\n<!-- 0723b --><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block;\" data-ad-client=\"ca-pub-6677469365582533\" data-ad-slot=\"4320035992\" data-ad-format=\"auto\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\u53c2\u8003\u8a18\u4e8b\uff09\u80c3\u6f70\u760d\u3084\u9006\u6d41\u6027\u98df\u9053\u708e\u306b\u5e45\u5e83\u304f\u51e6\u65b9\u3055\u308c\u308b\u80c3\u85ac\u300c\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u300d\u306f\u80c3\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u3092\u6700\u5927\u30678\u500d\u306b\u307e\u3067\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u3002\u305d\u3057\u3066\u8178\u5185\u7d30\u83cc\u74b0\u5883\u3092\u7834\u58ca\u3059\u308b\u793a\u5506\u3082 In Deep 2019\u5e749\u670830\u65e5 \u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b &hellip; <a href=\"https:\/\/nofia.net\/?p=19298\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u9006\u6d41\u6027\u98df\u9053\u708e\u3084\u80c3\u6f70\u760d\u306b\u5e83\u304f\u51e6\u65b9\u3055\u308c\u308b\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u306f\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u308b\u3068\u3044\u3046\u8ad6\u6587<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":18995,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-19298","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain"],"_links":{"self":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/19298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19298"}],"version-history":[{"count":3,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/19298\/revisions"}],"predecessor-version":[{"id":19712,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/19298\/revisions\/19712"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/media\/18995"}],"wp:attachment":[{"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}