{"id":16051,"date":"2023-11-29T09:45:21","date_gmt":"2023-11-29T00:45:21","guid":{"rendered":"https:\/\/nofia.net\/?p=16051"},"modified":"2023-11-29T09:45:21","modified_gmt":"2023-11-29T00:45:21","slug":"igg4-%e3%81%af%e3%80%8c%e3%82%ac%e3%83%b3%e3%82%92%e8%b6%85%e9%80%b2%e8%a1%8c%e6%80%a7%e3%81%ab%e3%81%99%e3%82%8b%e3%80%8d%e3%81%a8%e3%81%84%e3%81%86%e8%ab%96%e6%96%87","status":"publish","type":"post","link":"https:\/\/nofia.net\/?p=16051","title":{"rendered":"IgG4 \u306f\u300c\u30ac\u30f3\u3092\u8d85\u9032\u884c\u6027\u306b\u3059\u308b\u300d\u3068\u3044\u3046\u8ad6\u6587"},"content":{"rendered":"<p>&nbsp;<\/p>\n<hr \/>\n<h3><span style=\"color: #cb0000;\">\u30ac\u30f3\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059 IgG4 \u306b\u3088\u308b\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u3068\u514d\u75ab\u7642\u6cd5\u3078\u306e\u5f71\u97ff<\/span><\/h3>\n<p><span style=\"color: #808080; font-size: 10pt;\"><a href=\"https:\/\/jitc.bmj.com\/content\/8\/2\/e000661 \" target=\"_blank\" rel=\"noopener\">bmj.com<\/a> <\/span><\/p>\n<p><span style=\"color: #999999; font-size: 10pt;\">An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy<\/span><\/p>\n<p><span style=\"color: #800000; font-size: 14pt;\"><strong>\u6982\u8981<\/strong><\/span><\/p>\n<p><strong><span style=\"color: #800000;\">\u80cc\u666f\uff1a<\/span><\/strong><br \/>\n<span style=\"color: #000080;\">\u30ac\u30f3\u514d\u75ab\u7642\u6cd5\u306b\u304a\u3051\u308b\u6700\u8fd1\u306e\u76ee\u899a\u307e\u3057\u3044\u9032\u6b69\u306f\u3001\u4e3b\u306b\u7d30\u80de\u514d\u75ab\u306b\u7531\u6765\u3057\u3066\u3044\u308b\u304c\u3001\u767a\u30ac\u30f3\u306b\u304a\u3051\u308b\u4f53\u6db2\u6027\u514d\u75ab\u306e\u5f79\u5272\u306f\u3001\u3042\u307e\u308a\u7406\u89e3\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u3053\u308c\u307e\u3067\u306e\u89b3\u5bdf\u306b\u57fa\u3065\u3044\u3066\u3001\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u306e\u30b5\u30d6\u30bf\u30a4\u30d7 IgG4 \u304c\u30ac\u30f3\u306e\u514d\u75ab\u56de\u907f\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u7acb\u3066\u305f\u3002<\/span><\/p>\n<p><strong><span style=\"color: #800000;\">\u65b9\u6cd5\uff1a<\/span><\/strong><br \/>\n<span style=\"color: #000080;\">IgG4 \u306e\u5206\u5e03\u3001\u5b58\u5728\u91cf\u3001\u4f5c\u7528\u3001\u7279\u6027\u3001\u304a\u3088\u3073\u8003\u3048\u3089\u308c\u308b\u6a5f\u69cb\u3092\u3001\u30d2\u30c8\u306e\u30ac\u30f3\u30b5\u30f3\u30d7\u30eb\u3068\u52d5\u7269\u306e\u816b\u760d\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001in vitro \u304a\u3088\u3073 in vivo \u306e\u4e21\u65b9\u3067\u5e83\u7bc4\u306a\u6280\u8853\u3092\u7528\u3044\u3066\u8abf\u67fb\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #800000;\"><strong>\u7d50\u679c\uff1a<\/strong><\/span><br \/>\n<span style=\"color: #000080;\">\u98df\u9053\u30ac\u30f3\u60a3\u8005\u306e\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001\u30ac\u30f3\u7d44\u7e54\u3067\u306f IgG4 \u542b\u6709 B \u30ea\u30f3\u30d1\u7403\u3068 IgG4 \u6fc3\u5ea6\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3001\u30ac\u30f3\u60a3\u8005\u306e\u8840\u6e05\u3067\u306f IgG4 \u6fc3\u5ea6\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3069\u3061\u3089\u3082\u30ac\u30f3\u306e\u60aa\u6027\u5ea6\u306e\u5897\u52a0\u3068\u4e88\u5f8c\u4e0d\u826f\u306b\u6b63\u306e\u95a2\u9023\u304c\u3042\u308a\u3001\u3064\u307e\u308a\u3001<strong>IgG4 \u306e\u5897\u52a0\u306f\u30ac\u30f3\u306e\u5897\u6b96\u306e\u9032\u884c\u3068\u95a2\u9023\u3057\u3066\u3044\u308b<\/strong>\u3088\u3046\u3060\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3055\u3089\u306b\u3001IgG4 \u306f\u3001\u305d\u306e\u6297\u539f\u7279\u7570\u6027\u306b\u95a2\u4fc2\u306a\u304f\u3001in vitro \u3067\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6297\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u5a92\u4ecb\u6027\u7d30\u80de\u50b7\u5bb3\u3001\u6297\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u98df\u4f5c\u7528\u3001\u88dc\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3\u3068\u3044\u3063\u305f\u53e4\u5178\u7684\u306a\u514d\u75ab\u53cd\u5fdc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u3001\u305d\u306e Fc\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8<span style=\"color: #993300; font-size: 10pt;\">\uff08\u203b \u6297\u4f53\u306e\u5c3e\u90e8\u306b\u3042\u305f\u308b\u9818\u57df\uff09<\/span>\u304c\u3001\u30ac\u30f3\u6297\u539f\u306b\u7d50\u5408\u3057\u305f\u30ac\u30f3\u7279\u7570\u7684 IgG1 \u306e Fc\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3068\u53cd\u5fdc\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u307e\u305f\u3001IgG4 \u306f\u514d\u75ab\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u306e Fc \u53d7\u5bb9\u4f53\u306b\u53cd\u5fdc\u3059\u308b\u969b\u306b IgG1 \u3068\u7af6\u5408\u3059\u308b\u3053\u3068\u3082\u308f\u304b\u3063\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3057\u305f\u304c\u3063\u3066\u3001\u30ac\u30f3\u5fae\u5c0f\u74b0\u5883\u3067\u5c40\u6240\u7684\u306b\u5897\u52a0\u3057\u305f IgG4 \u306f\u3001\u6297\u4f53\u5a92\u4ecb\u6297\u30ac\u30f3\u53cd\u5fdc\u3092\u963b\u5bb3\u3057\u3001\u30ac\u30f3\u304c\u5c40\u6240\u514d\u75ab\u653b\u6483\u3092\u56de\u907f\u3057\u3066\u3001<strong>\u9593\u63a5\u7684\u306b\u30ac\u30f3\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b<\/strong>\u306f\u305a\u3060\u3002\u3053\u306e\u4eee\u8aac\u306f\u30013\u3064\u306e\u7570\u306a\u308b\u514d\u75ab\u5f37\u529b\u306a\u30de\u30a6\u30b9 \u30e2\u30c7\u30eb\u3067\u691c\u8a3c\u3055\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u6211\u3005\u306f\u3001IgG4 \u306e\u5c40\u6240\u9069\u7528\u306b\u3088\u308a\u3001\u63a5\u7a2e\u3055\u308c\u305f<strong>\u4e73\u30ac\u30f3\u3001\u7d50\u8178\u76f4\u8178\u30ac\u30f3\u3001\u304a\u3088\u3073\u767a\u30ac\u30f3\u7269\u8cea\u8a98\u767a\u6027\u76ae\u819a\u4e73\u982d\u816b\u306e\u5897\u6b96\u304c\u6709\u610f\u306b\u52a0\u901f\u3055\u308c\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f<\/strong>\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u307e\u305f\u3001\u30ac\u30f3\u514d\u75ab\u7642\u6cd5\u7528\u306e\u6297\u4f53\u533b\u85ac\u30cb\u30dc\u30eb\u30de\u30d6<span style=\"color: #993300; font-size: 10pt;\">\uff08\u203b \u30aa\u30d7\u30b8\u30fc\u30dc\uff09<\/span>\u3082\u30c6\u30b9\u30c8\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5b89\u5b9a\u5316 S228P \u5909\u7570\u3092\u6301\u3064\u672c\u8cea\u7684\u306b IgG4 \u3067\u3042\u308a\u3001\u30de\u30a6\u30b9\u306e\u30ac\u30f3\u5897\u6b96\u3092\u6709\u610f\u306b\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3053\u308c\u306f\u3001\u30ac\u30f3\u514d\u75ab\u7642\u6cd5\u306b\u95a2\u9023\u3057\u3066\u65b0\u305f\u306b\u51fa\u73fe\u3057\u305f\u8d85\u9032\u884c\u6027\u75be\u60a3\u306e\u8aac\u660e\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #800000;\"><strong>\u7d50\u8ad6\uff1a<\/strong><\/span><br \/>\n<span style=\"color: #000080;\">IgG4 \u306b\u306f\u3001\u3053\u308c\u307e\u3067\u8a8d\u8b58\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u304c\u3042\u308a\u3001\u30ac\u30f3\u306e\u5fae\u5c0f\u74b0\u5883\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u30ac\u30f3\u306e\u8a3a\u65ad\u3084\u514d\u75ab\u7642\u6cd5\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u3088\u3046\u3060\u3002<\/span><br \/>\n<script async src=\"https:\/\/wpagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6677469365582533\" crossorigin=\"anonymous\"><\/script><br \/>\n<!-- 0723b --><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block;\" data-ad-client=\"ca-pub-6677469365582533\" data-ad-slot=\"4320035992\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u30ac\u30f3\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059 IgG4 \u306b\u3088\u308b\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u3068\u514d\u75ab\u7642\u6cd5\u3078\u306e\u5f71\u97ff bmj.com An immune evasion mechanism with IgG4 playing an essent &hellip; <a href=\"https:\/\/nofia.net\/?p=16051\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">IgG4 \u306f\u300c\u30ac\u30f3\u3092\u8d85\u9032\u884c\u6027\u306b\u3059\u308b\u300d\u3068\u3044\u3046\u8ad6\u6587<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":16052,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[473,484],"tags":[],"class_list":["post-16051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vcs","category-ill-time"],"_links":{"self":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/16051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16051"}],"version-history":[{"count":1,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/16051\/revisions"}],"predecessor-version":[{"id":16053,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/16051\/revisions\/16053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/media\/16052"}],"wp:attachment":[{"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}