{"id":15406,"date":"2023-11-05T14:28:18","date_gmt":"2023-11-05T05:28:18","guid":{"rendered":"https:\/\/nofia.net\/?p=15406"},"modified":"2023-11-05T14:29:11","modified_gmt":"2023-11-05T05:29:11","slug":"%e3%83%8d%e3%82%a4%e3%83%81%e3%83%a3%e3%83%bc%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%9f%e3%81%93%e3%81%ae%e8%ab%96%e6%96%87%e3%81%af%e9%9d%9e%e5%b8%b8%e3%81%ab%e9%87%8d%e5%a4%a7%e3%81%aa","status":"publish","type":"post","link":"https:\/\/nofia.net\/?p=15406","title":{"rendered":"\u30cd\u30a4\u30c1\u30e3\u30fc\u306b\u63b2\u8f09\u3055\u308c\u305f\u3053\u306e\u8ad6\u6587\u306f\u975e\u5e38\u306b\u91cd\u5927\u306a\u6c17\u304c\u3059\u308b\u306e\u3067\u3059\u304c\u3001\u8a73\u7d30\u304c\u96e3\u89e3\u3059\u304e\u3066\u2026"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">SARS-CoV-2 \u306f\u80ba\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u81ea\u3089\u3092\u57cb\u3081\u8fbc\u3080\u2026\uff1f<br \/>\n<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u30a6\u30a4\u30eb\u30b9\u5de5\u5834\u306b\u5909\u3048\u3066\u3001\u534a\u5e74\u4ee5\u4e0a\u691c\u51fa\u3055\u308c\u306a\u3044\u307e\u307e\u306b\u3059\u308b\u2026\uff1f<br \/>\n<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u5f31\u3081\u308b\u2026\uff1f \uff08\u9055\u3046\u306e\u304b\u306a\u3042\uff09<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">\u3046\u30fc\u3093\u3001\u96e3\u3057\u904e\u304e\u3066\u3001\u5185\u5bb9\u3092\u628a\u63e1\u3067\u304d\u307e\u305b\u3093\u3002\u3069\u306a\u305f\u304b\u7406\u89e3\u3067\u304d\u308b\u65b9\u306e\u67fb\u8aad\u3092\u671f\u5f85\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"color: #808080;\">\u4ee5\u4e0b\u306f\u6982\u8981\u306e\u90e8\u5206\u3067\u3059\u3002<\/span><\/p>\n<hr \/>\n<h3><span style=\"color: #cb0000; font-size: 14pt;\">\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3051\u308b SARS-CoV-2 \u30a6\u30a4\u30eb\u30b9\u306e\u6301\u7d9a\u306f IFN-\u03b3 \u7d30\u80de\u3068 NK \u7d30\u80de\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b<\/span><\/h3>\n<p><span style=\"color: #808080; font-size: 10pt;\"><a href=\"https:\/\/www.nature.com\/articles\/s41590-023-01661-4 \" target=\"_blank\" rel=\"noopener\">nature.com<\/a> 2023\/11\/02<\/span><\/p>\n<p><span style=\"color: #999999;\"><strong><span style=\"font-size: 10pt;\">SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-\u03b3 and NK cells<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 14pt; color: #800000;\"><strong>\u6982\u8981<\/strong><\/span><\/p>\n<p><span style=\"color: #000080;\">\u91cd\u75c7\u6025\u6027\u547c\u5438\u5668\u75c7\u5019\u7fa4\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9 2 (SARS-CoV-2) \u306e RNA \u306f\u3001\u901a\u5e38\u3001\u611f\u67d3\u5f8c\u6570\u65e5\u307e\u305f\u306f\u6570\u9031\u9593\u5f8c\u306b\u306f\u4e0a\u6c17\u9053\u3067\u691c\u51fa\u3055\u308c\u306a\u304f\u306a\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u4eca\u56de\u79c1\u305f\u3061\u306f\u3001\u30de\u30ab\u30af\u30b6\u30eb\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001SARS-CoV-2 \u304c\u4f53\u5185\u306b\u5b58\u7d9a\u3059\u308b\u304b\u3069\u3046\u304b\u3001\u307e\u305f\u305d\u306e\u5b58\u7d9a\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4f55\u304b\u3092\u691c\u8a0e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u8907\u88fd\u80fd\u529b\u306e\u3042\u308b\u30a6\u30a4\u30eb\u30b9\u304c\u3001\u611f\u67d3\u5f8c 6\u304b\u6708\u3092\u8d85\u3048\u305f\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44 (BAL) \u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u691c\u51fa\u3055\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3051\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u306f\u7d30\u80de\u304b\u3089\u7d30\u80de\u3078\u3068\u8d77\u3053\u308a\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3 (IFN-\u03b3) \u306b\u3088\u3063\u3066\u963b\u5bb3\u3055\u308c\u305f\u3002\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3\u7523\u751f\u306f\u3001\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44\u306e NKG2r + CD8 + T\u7d30\u80de\u304a\u3088\u3073NKG2A lo \u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\uff08NK\uff09\u7d30\u80de\u3067\u6700\u3082\u5f37\u304f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u523a\u6fc0\u5f8c\u306e NKG2A lo NK\u7d30\u80de\u3067\u306f\u3055\u3089\u306b\u5897\u52a0\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3057\u304b\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u5b58\u7d9a\u3057\u3066\u3044\u308b\u30de\u30ab\u30af\u30b6\u30eb\u306e\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u3067\u306f\u3001I\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3\u306e\u7523\u751f\u304c\u4f4e\u4e0b\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3055\u3089\u306b\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3\u306f\u3001\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u4e0a\u306e\u4e3b\u8981\u7d44\u7e54\u9069\u5408\u6027\u8907\u5408\u4f53 (MHC)-E \u306e\u767a\u73fe\u3082\u4ea2\u9032\u3057\u3001\u304a\u305d\u3089\u304f\u3001\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u5a92\u4ecb\u6b7b\u6ec5\u3092\u963b\u5bb3\u3057\u305f\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u30a6\u30a4\u30eb\u30b9\u306e\u6301\u7d9a\u6027\u304c\u4f4e\u3044\u30de\u30ab\u30af\u30b6\u30eb\u306f\u3001\u8981\u7d44\u7e54\u9069\u5408\u6027\u8907\u5408\u4f53\u306e\u4f9d\u5b58\u6027\u963b\u5bb3\u3092\u9003\u308c\u305f\u9069\u5fdc\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u3092\u30de\u30a6\u30f3\u30c8\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\">\u3053\u306e\u767a\u898b\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3051\u308b SARS-CoV-2 \u306e\u6301\u7d9a\u3092\u5236\u5fa1\u3057\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u3066\u3044\u305f\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/span><br \/>\n<script async src=\"https:\/\/wpagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6677469365582533\" crossorigin=\"anonymous\"><\/script><br \/>\n<!-- 0723b --><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block;\" data-ad-client=\"ca-pub-6677469365582533\" data-ad-slot=\"4320035992\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; SARS-CoV-2 \u306f\u80ba\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u81ea\u3089\u3092\u57cb\u3081\u8fbc\u3080\u2026\uff1f \u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u30a6\u30a4\u30eb\u30b9\u5de5\u5834\u306b\u5909\u3048\u3066\u3001\u534a\u5e74\u4ee5\u4e0a\u691c\u51fa\u3055\u308c\u306a\u3044\u307e\u307e\u306b\u3059\u308b\u2026\uff1f \u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u5f31\u3081\u308b\u2026\uff1f \uff08\u9055\u3046\u306e\u304b\u306a\u3042\uff09 \u3046\u30fc\u3093\u3001\u96e3 &hellip; <a href=\"https:\/\/nofia.net\/?p=15406\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u30cd\u30a4\u30c1\u30e3\u30fc\u306b\u63b2\u8f09\u3055\u308c\u305f\u3053\u306e\u8ad6\u6587\u306f\u975e\u5e38\u306b\u91cd\u5927\u306a\u6c17\u304c\u3059\u308b\u306e\u3067\u3059\u304c\u3001\u8a73\u7d30\u304c\u96e3\u89e3\u3059\u304e\u3066\u2026<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":15037,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,473],"tags":[],"class_list":["post-15406","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-vcs"],"_links":{"self":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/15406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15406"}],"version-history":[{"count":2,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/15406\/revisions"}],"predecessor-version":[{"id":15408,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/15406\/revisions\/15408"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/media\/15037"}],"wp:attachment":[{"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}