{"id":12692,"date":"2023-07-25T08:27:58","date_gmt":"2023-07-24T23:27:58","guid":{"rendered":"https:\/\/nofia.net\/?p=12692"},"modified":"2023-07-25T08:27:58","modified_gmt":"2023-07-24T23:27:58","slug":"nac%ef%bc%88n-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e3%82%b7%e3%82%b9%e3%83%86%e3%82%a4%e3%83%b3%ef%bc%89%e3%81%af%e3%80%81%e3%82%b9%e3%83%91%e3%82%a4%e3%82%af%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af","status":"publish","type":"post","link":"https:\/\/nofia.net\/?p=12692","title":{"rendered":"NAC\uff08N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\uff09\u306f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3092\u300c\u5909\u5f62\u300d\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a ACE2 \u3078\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3059\u308b\uff08\u611f\u67d3\u3092\u9632\u3050\uff09\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u305f\u8ad6\u6587"},"content":{"rendered":"<p>&nbsp;<\/p>\n<hr \/>\n<h3><span style=\"color: #cb0000;\">N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u7528\u3044\u305fSARS-CoV-2\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u64b9\u4e71<\/span><\/h3>\n<p><span style=\"color: #808080; font-size: 10pt;\"><a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/07391102.2023.2234031?journalCode=tbsd20 \" target=\"_blank\" rel=\"noopener\">tandfonline.com<\/a> 2023\/07\/21<\/span><\/p>\n<p><span style=\"color: #999999;\"><strong><span style=\"font-size: 10pt;\">Conformational perturbation of SARS-CoV-2 spike protein using N-acetyl cysteine: an exploration of probable mechanism of action to combat COVID-19<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #993300;\"><strong>\u6982\u8981<\/strong><\/span><\/p>\n<p><span style=\"color: #333399;\">\u91cd\u75c7\u6025\u6027\u547c\u5438\u5668\u75c7\u5019\u7fa4\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9 2 (SARS-CoV-2) \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u611f\u67d3\u75c7\u306f\u3001\u81a8\u5927\u306a\u6b7b\u8005\u6570\u3068\u7d4c\u6e08\u7684\u5f71\u97ff\u3092\u4f34\u3046\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5bbf\u4e3b\u7d30\u80de\u4e0a\u306e\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d202(ACE2) \u53d7\u5bb9\u4f53\u3068\u306e\u975e\u5171\u6709\u7d50\u5408\u3092\u4ecb\u3057\u3066\u30d2\u30c8\u4e0a\u76ae\u7d30\u80de\u306b\u4ed8\u7740\u3059\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u30a4\u30f3\u30fb\u30b7\u30ea\u30b3<span style=\"color: #666699;\">\uff08\u203b \u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3092\u7528\u3044\u308b\u89e3\u6790\uff09<\/span>\u30d9\u30fc\u30b9\u306e\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u3001\u6eb6\u5a92\u306b\u30a2\u30af\u30bb\u30b9\u53ef\u80fd\u306a\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u306e\u6e1b\u5c11\u3092\u901a\u3058\u3066\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u7684\u306b\u6d3b\u6027\u306a\u7acb\u4f53\u69cb\u9020\u3092\u6df7\u4e71\u3055\u305b\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u305d\u306e\u69cb\u9020\u69cb\u9020\u3092\u5d29\u58ca\u3055\u305b\u308b\u3053\u3068\u304c\u3001ACE2\u9175\u7d20\u306b\u5bfe\u3059\u308b\u7d50\u5408\u89aa\u548c\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u611f\u67d3\u3092\u9632\u3050\u5b9f\u73fe\u53ef\u80fd\u306a\u6226\u7565\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9 <span style=\"color: #666699;\">\uff08\u203b \u69cb\u9020\u3068\u6a5f\u80fd\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\uff09<\/span>\u30c7\u30fc\u30bf\u306f\u3001\u81e8\u5e8a\u533b\u5b66\u3067\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u6297\u9178\u5316\u5264\u304a\u3088\u3073\u7c98\u6db2\u6eb6\u89e3\u5264\u3067\u3042\u308b N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3 (NAC) \u304c\u3001\u5929\u7136\u72b6\u614b\u3067\u306f\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u3057\u3066\u3044\u305f\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6eb6\u5a92\u306b\u30a2\u30af\u30bb\u30b9\u53ef\u80fd\u306a\u30b7\u30b9\u30c6\u30a4\u30f3\u6b8b\u57fa\u3068\u5171\u6709\u7d50\u5408\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u3055\u3089\u306b\u30a4\u30f3\u30fb\u30b7\u30ea\u30b3\u306e\u5206\u6790\u306e\u7d50\u679c\u3001NAC \u3068 Cys525 \u306e\u9078\u629e\u7684\u5171\u6709\u7d50\u5408\u306e\u5b58\u5728\u306b\u3088\u308a\u3001\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cd\u8981\u306a\u6b8b\u57fa\u306e\u7acb\u4f53\u7279\u7570\u7684\u914d\u5411\u304c\u4e71\u308c\u3001\u305d\u306e\u7d50\u679c\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u3068 ACE2 \u53d7\u5bb9\u4f53\u3068\u306e\u7d50\u5408\u89aa\u548c\u6027\u304c 3\u500d\u5f31\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u307b\u307c\u3059\u3079\u3066\u306e SARS-CoV-2 \u5909\u7570\u4f53\u306f\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u30b7\u30b9\u30c6\u30a4\u30f3\u6b8b\u57fa\u3092\u4fdd\u5b58\u3057\u3066\u3044\u305f\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u3053\u306e\u767a\u898b\u7d50\u679c\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e Cys-525 \u3092\u878d\u5408\u963b\u5bb3\u5264\u3068\u3057\u3066\u6a19\u7684\u3068\u3057\u3001\u751f\u4f53\u5185\u3067\u306e\u85ac\u7269\u4e88\u9632\u4f5c\u7528\u3068\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u305d\u306e\u6cbb\u7642\u53ef\u80fd\u6027\u306e\u3042\u308b\u6d3b\u6027\u3092\u63a2\u7d22\u3059\u308b\u305f\u3081\u306e NAC \u304a\u3088\u3073\u3001\u305d\u306e\u985e\u4f3c\u4f53\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306e\u5206\u5b50\u7684\u57fa\u790e\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n<p><span style=\"color: #333399;\">\u305f\u3060\u3057\u3001\u8003\u3048\u3089\u308c\u308b\u4f5c\u7528\u6a5f\u5e8f\u3092\u691c\u8a3c\u3059\u308b\u306b\u306f\u3001in vitro <span style=\"color: #666699;\">\uff08\u203b \u8a66\u9a13\u7ba1\u5185\u3067\u306e\u7814\u7a76\uff09<\/span>\u30a2\u30c3\u30bb\u30a4\u3068\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u57fa\u3065\u304f\u5b9f\u9a13\u304c\u5fc5\u8981\u3060\u3002<\/span><\/p>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6677469365582533\" crossorigin=\"anonymous\"><\/script><br \/>\n<!-- 0723b --><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block;\" data-ad-client=\"ca-pub-6677469365582533\" data-ad-slot=\"4320035992\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u7528\u3044\u305fSARS-CoV-2\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u64b9\u4e71 tandfonline.com 2023\/07\/21 Conformational perturbation of SARS- &hellip; <a href=\"https:\/\/nofia.net\/?p=12692\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">NAC\uff08N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\uff09\u306f\u3001\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3092\u300c\u5909\u5f62\u300d\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a ACE2 \u3078\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3059\u308b\uff08\u611f\u67d3\u3092\u9632\u3050\uff09\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u305f\u8ad6\u6587<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":12693,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[473],"tags":[],"class_list":["post-12692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vcs"],"_links":{"self":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/12692","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12692"}],"version-history":[{"count":1,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/12692\/revisions"}],"predecessor-version":[{"id":12694,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/12692\/revisions\/12694"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/media\/12693"}],"wp:attachment":[{"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12692"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12692"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}