{"id":11667,"date":"2023-05-30T08:40:09","date_gmt":"2023-05-29T23:40:09","guid":{"rendered":"https:\/\/nofia.net\/?p=11667"},"modified":"2023-05-30T08:40:09","modified_gmt":"2023-05-29T23:40:09","slug":"%e3%82%b3%e3%83%ad%e3%83%8a%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e4%b8%96%e7%95%8c%e3%81%a7%e3%81%ae%e7%b7%8f%e6%8e%a5%e7%a8%ae%e6%95%b0%e3%81%8c%e3%80%8c133%e5%84%84%e5%9b%9e%e3%80%8d","status":"publish","type":"post","link":"https:\/\/nofia.net\/?p=11667","title":{"rendered":"\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u4e16\u754c\u3067\u306e\u7dcf\u63a5\u7a2e\u6570\u304c\u300c133\u5104\u56de\u300d\u306b\u9054\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u77e5\u308b\u8ad6\u6587"},"content":{"rendered":"

 <\/p>\n

\u8ad6\u6587\u81ea\u4f53\u306e\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u30ef\u30af\u30c1\u30f3\u306f\u3001<\/span><\/p>\n

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\u3053\u3053\u306b\u51fa\u3066\u304f\u308b\u300c IgG4<\/strong> \u300d\u3068\u3044\u3046\u306e\u306f\u3001\u3042\u307e\u308a\u826f\u304f\u306a\u3044\u6297\u4f53\u306e\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u8a18\u4e8b\u306e\u5f8c\u534a\u3067\u3075\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

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\nIn Deep 2022\u5e7412\u670831\u65e5<\/span><\/p>\n

\n

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MDPI<\/a> 2023\/05\/17<\/span><\/p>\n

IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein<\/strong><\/span><\/p>\n

\u6982\u8981<\/strong><\/span><\/p>\n

\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9 SARS-CoV-2 \u304c\u4e16\u754c\u7684\u306b\u51fa\u73fe\u3057\u3066\u304b\u3089 1\u5e74\u3082\u7d4c\u305f\u306a\u3044\u3046\u3061\u306b\u3001mRNA \u6280\u8853\u306b\u57fa\u3065\u304f\u65b0\u3057\u3044\u30ef\u30af\u30c1\u30f3 \u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u304c\u5e02\u5834\u306b\u5c0e\u5165\u3055\u308c\u305f\u3002\u4e16\u754c\u4e2d\u3067\u3001\u3055\u307e\u3056\u307e\u306a\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3067\u7d04 133\u5104 8,000\u4e07\u56de\u5206\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u30ef\u30af\u30c1\u30f3\u304c\u6295\u4e0e\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

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\u3055\u3089\u306b\u3001\u6700\u8fd1\u306e\u8abf\u67fb\u3067\u306f\u3001mRNA \u30ef\u30af\u30c1\u30f3\u3092 2\u56de\u4ee5\u4e0a\u6ce8\u5c04\u3057\u305f\u4eba\u3005\u306e IgG4 \u30ec\u30d9\u30eb\u304c\u7570\u5e38\u306b\u9ad8\u3044\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002<\/span><\/p>\n

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IgG4 \u30ec\u30d9\u30eb\u306e\u5897\u52a0\u306f\u3001IgE \u8a98\u767a\u52b9\u679c\u306e\u963b\u5bb3\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30b2\u30f3\u7279\u7570\u7684\u514d\u75ab\u7642\u6cd5\u306e\u6210\u529f\u6642\u306b\u8d77\u3053\u308b\u514d\u75ab\u306e\u904e\u5270\u6d3b\u6027\u5316\u3068\u540c\u69d8\u306b\u3001\u514d\u75ab\u306e\u904e\u5270\u6d3b\u6027\u5316\u3092\u9632\u3050\u3053\u3068\u3067\u4fdd\u8b77\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u3057\u304b\u3057\u3001\u65b0\u305f\u306a\u8a3c\u62e0\u306f\u3001mRNA \u30ef\u30af\u30c1\u30f3\u3092\u7e70\u308a\u8fd4\u3057\u63a5\u7a2e\u3057\u305f\u5f8c\u306b\u691c\u51fa\u3055\u308c\u308b IgG4 \u30ec\u30d9\u30eb\u306e\u5897\u52a0\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u306f\u9632\u5fa1\u6a5f\u69cb\u3067\u306f\u306a\u3044\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u305d\u308c\u3088\u308a\u3082\u3001\u3053\u308c\u306f\u3001\u81ea\u7136\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u5fdc\u7b54\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7121\u62b5\u6297\u306e SARS-CoV2 \u611f\u67d3\u3068\u8907\u88fd\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5bdb\u5bb9\u6a5f\u69cb\u3092\u69cb\u6210\u3059\u308b\u3002<\/span><\/p>\n

\u9ad8\u6297\u539f\u6fc3\u5ea6\u306e mRNA \u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u7e70\u308a\u8fd4\u3059\u3053\u3068\u306b\u3088\u308b IgG4 \u5408\u6210\u306e\u5897\u52a0\u3082\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u611f\u53d7\u6027\u306e\u3042\u308b\u500b\u4eba\u3067\u306f\u30ac\u30f3\u306e\u5897\u6b96\u3084\u81ea\u5df1\u514d\u75ab\u6027\u5fc3\u7b4b\u708e\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

  \u8ad6\u6587\u81ea\u4f53\u306e\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u30ef\u30af\u30c1\u30f3\u306f\u3001 \u30fb\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306e\u30ea\u30b9\u30af\u304c\u3080\u3057\u308d\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b \u30fb\u30ac\u30f3\u306e\u5897\u6b96\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b \u3053\u3068\u304c\u66f8\u304b\u308c\u3066\u3042\u308b\u610f\u5473\u6df1\u3044\u3082\u306e\u3067\u3059\u304c\u3001133\u5104\u56de\u3068 … \u7d9a\u304d\u3092\u8aad\u3080 \u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u4e16\u754c\u3067\u306e\u7dcf\u63a5\u7a2e\u6570\u304c\u300c133\u5104\u56de\u300d\u306b\u9054\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u77e5\u308b\u8ad6\u6587<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":11065,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[473],"tags":[],"class_list":["post-11667","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vcs"],"_links":{"self":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/11667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11667"}],"version-history":[{"count":1,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/11667\/revisions"}],"predecessor-version":[{"id":11668,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/posts\/11667\/revisions\/11668"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=\/wp\/v2\/media\/11065"}],"wp:attachment":[{"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nofia.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}